One of the cannabinoids found in Cannabis sativa that has seen the most study is cannabidiol (CBD). Besides cannabidiol, tetrahydrocannabinol is another popular cannabinoid (THC). Among the more than 540 chemical components found in the Cannabis sativa plant are the psychoactive substances THC and CBD. Reliable Sourcing. For a high quality selection of Gelato 41 strain, you can shop here.
Cannabinoids, such as CBD and THC, interact with the brain through binding to cannabinoid receptors. The psychoactive ingredient in marijuana is tetrahydrocannabinol, or THC. CBD, however, does not have this consequence. In its place, it provides a wide range of possible positive effects on health.
The pharmacological effects of CBD have been suggested by reliable sources to be quite strong. CBD’s anti-inflammatory qualities are well-known among scientists and researchers. It reduces inflammation by inhibiting specific enzymes.
The role of CBD in treating anxiety.
Hemp’s phytocannabinoids stimulate the endocannabinoid system (ECS) in a manner similar to that of endogenous cannabinoids. For example, THC binds to cannabinoid receptors in the ECS by acting like our own endocannabinoids. However, CBD’s effects on the ECS are less pronounced than those it has on other sections of the system.
In contrast, CBD disrupts the ECS’s enzyme function, preventing the breakdown of endogenous cannabinoids like anandamide. Reducing its breakdown increases anandamide levels in the brain, which has positive effects on mood and anxiety.
In addition, CBD can activate our serotonin receptors directly, leading to an anti-anxiety effect via a mechanism distinct from the ECS. Plus, it enhances gamma-Aminobutyric acid’s (GABA) sedative actions in the brain, making it an even more potent anti-anxiety agent in general.
Treatment of Anxiety Disorders with CBD
CBD was examined in a modest clinical research on people with social anxiety disorder (SAD) and healthy controls in 2011[1]. The participants took a simulated public speaking test (SPST), a typical anxiety test. CBD dramatically reduced anxiety and discomfort in the SAD patients, compared to a placebo. Their decreased anxiety was actually on par with that of the control group.
In a 2019 study, researchers compared three different doses of CBD (150mg, 300mg, and 600mg) against a placebo in a group of males undergoing an SPST. Participants’ anxiety during the speech was considerably reduced by 300 milligrammes of CBD compared to a placebo, but not by 150 milligrammes or 600 milligrammes. These findings demonstrate the importance of considering the individual’s response to CBD and the fact that more CBD is not always better.
Another 2019 study evaluated the effects of CBD at far lower dosages than previous clinical trials. Participants in this study took either 25 milligrammes of CBD per day or 50 milligrammes or 75 milligrammes per day[3]. Researchers anticipated that individuals would find it difficult to afford bigger doses in their daily lives, and that smaller doses would still show useful. In fact, most people report feeling less anxious during the first month and continuing to feel that way afterward. Though it fluctuated more than worry, the quality of sleep also increased. Fortunately, just three people experienced negative reactions.
CBD for Stress and Mood Disorders
In 2020, scientists examined the effects of CBD oil on 397 patients suffering from a wide range of conditions at varied dosages[4]. Both participants’ anxiety and despair levels, as well as their ability to engage in their regular activities, decreased significantly after receiving treatment for non-cancer pain or mental health-related symptoms. They also appeared to experience significant pain reduction after using CBD oil.
Cannabidiol as a Treatment for Post-Traumatic Stress Disorder and Related Ph
A 2019 study with only 11 participants indicated that patients with posttraumatic stress disorder (PTSD) experienced less severe symptoms when CBD was added to their regular psychiatric treatment.[5] CBD was given orally and was well tolerated by all participants.
When combined with THC, other research suggests CBD can lessen PTSD symptoms. An “entourage effect” is produced when THC and CBD are combined; the former amplifies the latter’s effects, while the latter mitigates the former’s[7].
Exposure treatment, which helps patients disassociate particular stimuli with a fear response, and cognitive behavioural therapy may also benefit from the addition of CBD, according to some research.
How Much CBD Should You Take If You Have Anxiety
Finding the optimal CBD dose for your anxiety is also essential. Experts recommend easing into it and working up to your desired intensity level gradually.
Often, researchers in clinical trials will test extremely high doses. Particularly effective doses tested for easing anxiety include:
Patients with SAD who took 600 mg were able to simulate normal speaking in an oral communication experiment[10].
In a speech simulation including male patients, 300 mg was used [11].
Other studies, however, have shown that very smaller doses are also quite beneficial in reducing anxiety.
In addition to standard psychiatric care, daily dosages of 33–49 milligrammes have been shown to improve PTSD symptoms[13].
Another large-scale study found that patients responded well to CBD doses ranging from 40 to 300 mg per day, providing more evidence that CBD dosage needs to be tailored to each individual’s symptoms and physiology.
A Guide to Using CBD Oil
Full-spectrum CBD oil, broad-spectrum CBD oil, and CBD isolate all exist. While some benefits can be gained from using an isolate, a full- or broad-spectrum oil may provide a more comprehensive experience. Reason being, besides CBD, they also include all the other phytonutrients naturally present in hemp. The “entourage effect,” or the idea that the whole plant profile is greater than the sum of its parts, is the result of the synergy created by the phytonutrients. To put it another way, nature intended for all of the plant’s chemicals to operate together, therefore separating them reduces the efficacy of each compound individually.
It’s important to note that not all of the cannabinoids found in hemp are included in broad-spectrum CBD oil. If you’re looking for the complete entourage effect, full-spectrum CBD oil is your best bet because it retains the plant’s whole profile after extraction. The lack of oversight in the business makes it difficult to locate full-spectrum CBD oils that have all the claimed phytonutrients.
A Guide to Using CBD Oil
Full-spectrum CBD oil, broad-spectrum CBD oil, and CBD isolate all exist. While some benefits can be gained from using an isolate, a full- or broad-spectrum oil may provide a more comprehensive experience. Reason being, besides CBD, they also include all the other phytonutrients naturally present in hemp. The “entourage effect,” or the idea that the whole plant profile is greater than the sum of its parts, is the result of the synergy created by the phytonutrients. To put it another way, nature intended for all of the plant’s chemicals to operate together, therefore separating them reduces the efficacy of each compound individually.
It’s important to note that not all of the cannabinoids found in hemp are included in broad-spectrum CBD oil. If you’re looking for the complete entourage effect, full-spectrum CBD oil is your best bet because it retains the plant’s whole profile after extraction. The lack of oversight in the business makes it difficult to locate full-spectrum CBD oils that have all the claimed phytonutrients.